Introduction

The NeuLive wireless system allows researchers to perform electrophysiological measurements and deliver precise electrical stimulations to the brain, heart, and muscles of commonly used preclinical research models, including mice, rats, pigs, and non-human primates.

Features

Wireless. Lightweight.
Stimulation and Recording.

Wireless transmission

Wireless devices allow for natural behavior observation and reduce animal stress, thereby enhancing data reliability

Stim/Rec. with the same channel

Rapid switch between recording and stimulation enables real-time effects analysis with high temporal and spatial resolution

Incredibly lightweight device

Lightweight devices address ethical concerns by minimizing animal discomfort, promoting natural behaviors, and ensuring more reliable data

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Application

In Vivo Electrophysiology

Electrophysiology plays a pivotal role in both neuroscientific and cardiovascular research. It enables researchers to explore the fundamental electrical properties of cells, including neurons and muscle cells, using invasive and non-invasive methods (EEG, ECG, EMG). These electrophysiological measurements prove valuable in tracking brain and muscle activity during various conditions such as sleep-wake cycles, seizures, Parkinson's Disease, and treatment-induced effects.

Parkinson’s Disease Monitoring

NeuLive serves as a revolutionary tool in the realm of Parkinson's Disease (PD) research. Its lightweight design ensures minimal discomfort for commonly used PD models including rats and mice. By integrating both wireless neural signal recording and stimulation, researchers can dynamically study PD's neurophysiological changes and test potential interventional strategies simultaneously. Real-time monitoring brings about unparalleled insights into PD progression and therapeutic responses.

Acute recording to increase the chance of accessing the target brain area
Chronic recording to detect beta oscillation

Addiction

NeuLive is pivotal in addiction research, enabling real-time neural activity tracking during substance exposure. Its dual amplification and stimulation capabilities allow researchers to probe brain circuits linked to addiction and potentially modulate them, offering insights into both mechanisms and treatments. Being wireless and ultra-lightweight, NeuLive ensures animals exhibit naturalistic behaviors, making it an invaluable asset for understanding addiction's neural underpinnings.

Chronic recording during the conditioning and testing

Sleep/Wake Monitoring

Brain oscillation is essential for understanding the sleep pattern. With NeuLive, we are able to continuously monitor sleep activity and the effect of therapeutics on sleep patterns using both ECoG and EMG.

Chronic 24 H continuous recording
ECoG with spectral analysis
Neck EMG to assist wake detection
Detection of NREM sleep and REM sleep

In Vivo Electrical Neuromodulation

Electrical neuromodulation offers a powerful means to modulate brain activity naturally and effectively. Whether through invasive or non-invasive electrode-based approaches, programmed electrical neuromodulation can be precisely directed to specific brain regions or surface structures, making it a valuable tool for addressing a wide range of neurological disorders, pain management, and cognitive function enhancement.

Closed-loop electrical stimulation

Closed-loop electrical stimulation, when programmed to respond to pathophysiological signals or markers, represents a promising alternative to open-loop stimulation protocols. This approach triggers stimulation in a more adaptive and patient-specific manner. Notably, the application of closed-loop stimulation has demonstrated significant efficacy in the treatment of patients with Parkinson's Disease.

Temporal interference stimulation

Temporal interference stimulation is an innovative neurostimulation technique that offers significant advantages. It excels in precision, allowing for targeted modulation of specific brain regions by applying multiple electric fields with slightly different frequencies. This non-invasive approach makes it particularly valuable for treatments requiring deep brain stimulation without invasive procedures.

Sine wave/Pulse stimulation

Sine wave and pulse stimulation methods are versatile and widely applied forms of electrical stimulation. They offer flexibility for various medical and research purposes.

Publication

Changes in diurnal brain activity of rats with impaired dopaminergic system: Implications to biomarker discovery for theParkinson's disease

Annual Meeting of Society for Neuroscience, 2023
TY Yen, JW Yang, YH Kuo, YC Chang, and H Chen
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Product: NeuLive

Quantitative monitoring of neuronal regeneration by functional assay and wireless neural recording

Annual Meeting of Society for Neuroscience, 2023
JW Yang, MZ Liang, H Chen, and L Chen

Product: NeuLive

Utilizing Stereoencephalography Technology to Monitor Epilepsy in Freely Moving Miniature Swine

Annual Meeting of Society for Neuroscience, 2023
HC Pa, CM Ye, YMa, Jw Ya,Y W, HC
‍
Product: NeuLive

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